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A549 has also been employed in viral research and associated protein expression changes as a consequence of viral infection. [10] Although A549 is a cancer cell line, it has also been studied for its response to tuberculosis, specifically the production of chemokines as it is induced by the invading bacteria. [11]
To further confirm that endogenous wild-type p53 is really causing the repression of survivin gene expression, the authors induced A549 (human lung cancer cell line with wild-type p53) and T47D (human breast cancer cell line with mutant p53) cells with DNA-damaging agent adriamycin to trigger the physiological p53 apoptotic response in these ...
An immortalised cell line is a population of ... A549 cells – derived from a cancer patient lung ... a widely used human cell line isolated from cervical cancer ...
The Atlas is part of the genome project and participates in research on cancer epidemiology. The Atlas is accessed by: 1- researchers in cytogenetics, molecular biology, cell biology; 2- clinicians, haematologists, cytogeneticists, pathologists, from the university hospitals, indeed, but also from general hospitals where the Atlas is one of the ...
A549: Human: Lung: Human alveolar adenocarcinoma cell line - A549 cultured by MLM at different time points and cell numbers. [9] Immunohistochemistry (IHC) reveals epithelial markers on A549 after culturing in 3D with the MLM. Type II alveolar [9] Primary: Human: Lung: Human tracheal smooth muscle cells (HTSMCs) [9] Primary: Human: Lung: HTSMCs ...
A549 cells share the same characteristics with the alveolar type II cells. This are type II pneumocytes crucial for lung homeostasis, and regeneration upon damage. For research purposes to unravel different molecular mechanisms leading to lung diseases, A549 cells serves as a good model to which translational research can be relied upon.
In lung adenocarcinoma cell line A549 overexpression of IRS-1 leads to reduced growth. Tumor infiltrating neutrophils have recently been thought to adjust tumor growth and invasiveness. Neutrophil elastase is shown to degrade IRS-1 by gaining access to endosomal compartment of carcinoma cell. IRS-1 degradation induces cell proliferation in ...
233081 Ensembl ENSG00000126266 ENSMUSG00000044453 UniProt O14842 Q76JU9 RefSeq (mRNA) NM_005303 NM_194057 RefSeq (protein) NP_005294 NP_918946 Location (UCSC) Chr 19: 35.35 – 35.35 Mb Chr 7: 30.56 – 30.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Free fatty acid receptor 1 (FFAR1), also known as G-protein coupled receptor 40 (GPR40), is a rhodopsin-like G-protein coupled ...
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