Search results
Results from the WOW.Com Content Network
Guanidine can be obtained from natural sources, being first isolated in 1861 by Adolph Strecker via the oxidative degradation of an aromatic natural product, guanine, isolated from Peruvian guano. [8] [9] A laboratory method of producing guanidine is gentle (180-190 °C) thermal decomposition of dry ammonium thiocyanate in anhydrous conditions:
Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 "Spanish flu", so that it can be studied safely.. Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them.
Guanidinium chloride is a weak acid with a pK a of 13.6. The reason that it is such a weak acid is the complete delocalization of the positive charge through three nitrogen atoms (plus a little bit of positive charge on carbon).
Tetramethylguanidine is an organic compound with the formula HNC(N(CH 3) 2) 2. This colourless liquid is a strong base, as judged by the high pK a of its' conjugate acid. [2] It was originally prepared from tetramethylthiourea via S-methylation and amination, but alternative methods start from cyanogen iodide. [3]
Guanidine nitrate is the chemical compound with the formula [C(NH 2) 3]NO 3. It is a colorless, water-soluble salt. It is produced on a large scale and finds use as precursor for nitroguanidine, [1] fuel in pyrotechnics and gas generators. Its correct name is guanidinium nitrate, but the colloquial term guanidine nitrate is widely used.
A carbonate is a salt of carbonic acid, (H 2 CO 3), [2] characterized by the presence of the carbonate ion, a polyatomic ion with the formula CO 2− 3. The word "carbonate" may also refer to a carbonate ester , an organic compound containing the carbonate group O=C(−O−) 2 .
TRIzol reagent contains guanidinium thiocyanate and phenol.. TRIzol is a widely used [1] chemical solution used in the extraction of DNA, RNA, and proteins from cells. The solution was initially used and published by Piotr Chomczyński and Nicoletta Sacchi in 1987.
2-Cyanoguanidine is a nitrile derived from guanidine. It is a dimer of cyanamide, from which it can be prepared. 2-Cyanoguanidine is a colourless solid that is soluble in water, acetone, and alcohol, but not nonpolar organic solvents. [1]