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The William Lynch speech, also known as the Willie Lynch letter, is an address purportedly delivered by a William Lynch (or Willie Lynch) to an audience on the bank of the James River in Virginia in 1712 regarding control of slaves within the colony. [1] In recent years, it has been widely exposed as a hoax. [2] [3]
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
In 1782, Charles Lynch wrote that his assistant had administered Lynch's law to Tories "for Dealing with the negroes &c". [10] Charles Lynch was a Virginia Quaker, [11]: 23ff planter, and Patriot who headed a county court in Virginia which imprisoned Loyalists during the American Revolutionary War, occasionally imprisoning them for up to a year ...
At least 2 successive generations involved; At least 1 of the cancers diagnosed before age 50. [5] These criteria were found to be too strict and were expanded to include the associated non-colorectal cancers in 1998. These were called the Amsterdam II clinical criteria for families with Lynch syndrome. [4] [6]
Charles Lynch's extralegal actions were legitimized by the Virginia General Assembly in 1782. [1] In 1811, Captain William Lynch claimed that the phrase "Lynch's Law", already famous, actually came from a 1780 compact signed by him and his neighbours in Pittsylvania County, Virginia, to uphold their own brand of law independent of legal authority.
An enslaver by the name of Willie Lynch was said to have allegedly written a pamphlet that widely circulated instructing enslavers on how to use brutality to control enslaved people. "The Willie ...
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Under the name constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. [2] Monoallelic mutations of these genes are observed in the condition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer, while biallelic mutations are observed in CMMR-D. [3] People expressing the HNPCC (which itself is considered autosomal dominant) trait are ...