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The amygdala, cerebellum, and many other brain regions have been implicated in autism. [15]Unlike some brain disorders which have clear molecular hallmarks that can be observed in every affected individual, such as Alzheimer's disease or Parkinson's disease, autism does not have a unifying mechanism at the molecular, cellular, or systems level.
More recent MRI studies have reported age-related regional decreases in cerebral volume. [6] [7] Regional volume reduction is not uniform; some brain regions shrink at a rate of up to 1% per year, whereas others remain relatively stable until the end of the life-span. [8]
Autism in Adulthood is a quarterly peer-reviewed academic journal covering research across a range of disciplines on all aspects of autism spectrum disorders in adults. It was established in 2019 and is published by Mary Ann Liebert. The founding editor-in-chief is Christina Nicolaidis (Portland State University). [1]
The Journal of Autism and Developmental Disorders is a monthly peer-reviewed medical journal covering research on all aspects of autism spectrum disorders and related developmental disabilities. The journal was established in 1971 as the Journal of Autism and Childhood Schizophrenia , obtaining its current title in 1979. [ 1 ]
Mostly in the frontal cortex, these differences often stem from a smaller brain volume, and the decreased blood flow that results influences the hypofrontality. [9] It has not been determined if the reduction of the frontal cortex is the ultimate cause of the symptoms, or if the condition worsens as the symptoms develop.
The volume of the human brain has increased as humans have evolved (see Homininae), starting from about 600 cm 3 in Homo habilis up to 1680 cm 3 in Homo neanderthalensis, which was the hominid with the biggest brain size. [7] Some data suggest that the average brain size has decreased since then. [8]
The brain volume decreases roughly 5% per decade after forty. It is currently unclear why brain volume decreases with age. However, a few causes may include cell death, decreased cell volume, and changes in synaptic structure.
Molecular Autism is a peer-reviewed open-access medical journal covering research on the cause, biology, and treatment of autism and related neurodevelopmental disorders. The journal was established in 2010 and is published by BioMed Central .