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A single cyclin A gene has been identified in Drosophila while Xenopus, mice and humans contain two distinct types of cyclin A: A1, the embryonic-specific form, and A2, the somatic form. Cyclin A1 is prevalently expressed during meiosis and early on in embryogenesis. Cyclin A2 is expressed in dividing somatic cells. [7]
890 12428 Ensembl ENSG00000145386 ENSMUSG00000027715 UniProt P20248 P51943 RefSeq (mRNA) NM_001237 NM_009828 RefSeq (protein) NP_001228 NP_033958 Location (UCSC) Chr 4: 121.82 – 121.82 Mb Chr 3: 36.62 – 36.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is ...
The lethal-7 (let-7) gene was first discovered in the nematode C. elegans as a key developmental regulator and became one of the first two known microRNAs (the other one is lin-4). [8] Soon, let-7 was found in the fruit fly (Drosophila), and identified as the first known human miRNA by a BLAST (basic local alignment search tool) research. [9]
The gap genes code for transcription factors that regulate the expression of pair-rule genes and homeotic genes [8] by competing for binding to their enhancer regions. It has been demonstrated that gap gene expression in the Drosophila blastoderm exhibit a property called canalization, a property of developing organisms to produce a consistent phenotype despite variations in genotype or ...
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...
Therefore, dsRNAs control gene expression via sequence complementarity. S2 cells were then transfected with Drosophila cyclin E dsRNA. Cycline E is an essential gene for cell cycle progression into the S phase. Cyclin E dsRNA arrested the cell cycle at the G 1 phase (before the S phase). Therefore, RNAi can target endogenous genes.
Hints for Today's Connections Sports Edition Categories on February 25, 2025. Here are some hints about the four categories to help you figure out the word groupings.
In other members of Drosophila, functional orthologs of the D. melanogaster cycle gene can either be found in chromosome 3 or in scaffold/matrix attachment regions. In each case, the orthologs retain functional PAS domains, signal transduction function, and transcription factor activity.