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The main source of polyphenols is dietary, since they are found in a wide array of phytochemical-bearing foods.For example, honey; most legumes; fruits such as apples, blackberries, blueberries, cantaloupe, pomegranate, cherries, cranberries, grapes, pears, plums, raspberries, aronia berries, and strawberries (berries in general have high polyphenol content [5]) and vegetables such as broccoli ...
On the contrary, research indicates that although polyphenols are antioxidants in vitro, antioxidant effects in vivo are probably negligible or absent. [3] [4] [5] By non-antioxidant mechanisms still undefined, polyphenols may affect mechanisms of cardiovascular disease or cancer. [6]
Proanthocyanidins are a class of polyphenols found in many plants, such as cranberry, blueberry, and grape seeds. Chemically, they are oligomeric flavonoids. Many are oligomers of catechin and epicatechin and their gallic acid esters. More complex polyphenols, having the same polymeric building block, form the group of condensed tannins.
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Mainly found in the fruit skins and seeds, high levels of polyphenols may reflect only the measured extractable polyphenol (EPP) content of a fruit which may also contain non-extractable polyphenols. Black tea contains high amounts of polyphenol and makes up for 20% of its weight. [20] Concentration can be made by ultrafiltration. [21]
As part of their adaptation from marine life, terrestrial plants began producing non-marine antioxidants such as ascorbic acid (), polyphenols, and tocopherols.The evolution of angiosperm plants between 50 and 200 million years ago resulted in the development of many antioxidant pigments – particularly during the Jurassic period – as chemical defences against reactive oxygen species that ...
There are three ways to test if a fruit interacts with drugs: Test a drug–fruit combination in humans [11] Test a fruit chemically for the presence of the interacting polyphenol compounds; Test a fruit genetically for the genes needed to make the interacting polyphenol compounds [32] The first approach involves risk to trial volunteers.
Others, such as some polyphenols and flavonoids, may be pro-oxidants in high ingested amounts. [23] Non-digestible dietary fibers from plant foods, often considered as a phytochemical, [24] are now generally regarded as a nutrient group having approved health claims for reducing the risk of some types of cancer [25] and coronary heart disease. [26]