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2. Cialis Side Effects: What to Expect (& How to Avoid Them) - AOL

   www.aol.com/cialis-side-effects-expect-avoid...

   According to a 2008 review of studies on tadalafil, 15 percent of men who used this medication at its highest recommended dose (20 milligrams) experienced headaches.

3. Tadalafil: Your Ultimate Guide to Dosages, Side Effects & More

   www.aol.com/tadalafil-ultimate-guide-dosages...

   Daily dose tadalafil is available at a dosage of 2.5mg or 5mg tablets. There might be several reasons to go with daily dosages instead of the dosages where you take the medication as needed.

4. Is It Safe to Take Cialis Daily? - AOL

   www.aol.com/safe-cialis-daily-115900442.html

   Unlike other ED medications, such as Viagra® (sildenafil) and Levitra® (vardenafil), which work for four to five hours per dose, Cialis® (which contains the active ingredient tadalafil) is a ...

5. Tadalafil - Wikipedia

   en.wikipedia.org/wiki/Tadalafil

   Tadalafil is an annulated 2,5-diketopiperazine. [25] It is also a 1,2,3,4-tetrahydro-β-carboline. Tadalafil can be synthesized starting from (D)-tryptophan methyl ester and piperonal via a Pictet–Spengler reaction. This is followed by condensations with chloroacetyl chloride and methylamine to complete the diketopiperazine ring: [26]

6. Talk:Tadalafil - Wikipedia

   en.wikipedia.org/wiki/Talk:Tadalafil

   Here are links to possibly useful sources of information about Tadalafil. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC

7. 4 Common ED Pills: Weighing the Pros & Cons of Each - AOL

   www.aol.com/4-common-ed-pills-weighing-141800609...

   Tadalafil has a half-life of 17.5 hours — it remains active in your body for far longer than other ED medications. A single dose of tadalafil can improve blood flow to your privates and make it ...

8. Discovery and development of phosphodiesterase 5 inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   This allows for a longer therapeutic window and is therefore often a more convenient drug than others with a shorter therapeutic window. Tadalafil is more bioavailable (80%) than sildenafil (40%) and vardenafil (15%) but it has a slow absorption, or about 2 hours compared to 50 minutes of sildenfil. Vardenafil is most known for its potency. [24]

9. What Is the Safest ED Medication? - AOL

   www.aol.com/safest-ed-medication-105700669.html

   Tadalafil is available as brand name Cialis and as a generic medication. It can be used as needed before intimate activity or taken daily at a reduced dosage to provide ongoing ED relief. Vardenafil .