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Indole-3-carbaldehyde (I3A), also known as indole-3-aldehyde and 3-formylindole, is a metabolite of dietary L-tryptophan which is synthesized by human gastrointestinal bacteria, particularly species of the Lactobacillus genus.
Non-small cell lung cancer, oesophageal cancer, uterine cervical cancer, head and neck cancer and urothelial cancer: Nephrotoxicity, myelosuppression and nausea and vomiting (30-90%). Oxaliplatin: IV: Reacts with DNA, inducing apoptosis, non-cell cycle specific. Colorectal cancer, oesophageal cancer and gastric cancer
At very low concentrations, however, it has a flowery smell, [3] and is a constituent of many perfumes. It also occurs in coal tar. It has been identified in cannabis. [4] It is the main volatile compound in stinky tofu. [5] When indole is a substituent on a larger molecule, it is called an indolyl group by systematic nomenclature.
The process begins by producing 7-chloroindole-3-acetamide by treating 7-chloroindole with a series of reagents, shown farther down. This molecule is then glycosylated and reacted with methyl 7-chloroindole-3-glyoxylate to produce an intermediate that goes on to stabilize into the final product.
Indole-3-carbinol induces a G1 growth arrest of human reproductive cancer cells. [9] This is potentially relevant to the prevention and treatment of cancer, as the G1 phase of cell growth occurs early in the cell life cycle, and, for most cells, is the major period of cell cycle during its lifespan.
In addition to the light- or H 2 O 2-induced formation of FICZ, a number of other enzymatic pathways have been identified to convert Trp to FICZ via the precursor I3A. [2] [3] Oxidative deamination of Trp by aromatic amino acid aminotransferases (ArAT) or L-amino oxidases (LAAO), one of which is the IL4-inducible enzyme IL4I1, converts Trp to indole-3-pyruvate, which after decarboxylation ...
5-ARIs are clinically used in the treatment of conditions that are exacerbated by DHT: [3] Mild-to-moderate benign prostatic hyperplasia and lower urinary tract symptoms; Pattern hair loss in both men and women; 5-ARIs can be used in the treatment of hirsutism in women. [1] The usefulness of 5-ARIs for the potential treatment of acne is uncertain.
In the United States, endometrial cancer is the most frequently diagnosed gynecologic cancer and, in women, the fourth most common cancer overall, [11] [20] representing 6% of all cancer cases in women. [92] In that country, as of 2014 it was estimated that 52,630 women were diagnosed yearly and 8,590 would die from the disease. [27]