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An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system.
Schematic of the Emulate liver-chip [4] Emulate's Organs-on-Chips technology has been used to recreate the function of a variety of different organs, including the liver, intestine, brain, kidney, and lung. [5] The company's Organ-Chips are about the size of a AA battery and feature two fluidic channels that create the flow of blood and other ...
Organ printing technology can also be combined with microfluidic technology to develop organs-on-chips. [29] These organs-on-chips have the potential to be used for disease models, aiding in drug discovery, and performing high-throughput assays. [29] Organ-on-chips work by providing a 3D model that imitates the natural extracellular matrix ...
Schematic drawing of a lung-on-a-chip. The membrane in the middle can be stretched by vacuum in the two side chambers. Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1]
Organ chips are devices containing hollow microvessels filled with cells simulating tissue and/or organs as a microfluidic system that can provide key chemical and electrical signal information. [48] This is distinct from an alternative use of the term microchip , which refers to small, electronic chips that are commonly used as an identifier ...
A substitute of blood flows through micro-channels where the compartments of chips linked. When injected, the test drug circulates around the device, mimicking what goes in the body on a micro scale. Sensors in the chip transfer information for computer analysis. [34] Another name for this chip is the microfluidic chip is cell-bio chips.
A prominent example of an intestine-on-a-chip system relying on architectural cues is the homeostatic mini-intestines by Nikolaev et al. [24] They use microfabricated intestine-on-a-chip devices with a hydrogel chamber. The collagen-Matrigel-mix hydrogel is laser-ablated to generate a microchannel for a tubular intestinal lumen with crypt ...
Mimetas is a privately owned biotechnology company developing human organ-on-a-chip tissue models and products for drug development.The company also is involved in the testing of chemicals along with food and personalized medicine applications.
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