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An old bottle of AA Hyde Mentholatum Ointment. A.B.C. Liniment was used from approximately 1880 to 1935. [2] [3] It was named for its three primary ingredients: aconite, belladonna, and chloroform. [2] There were numerous examples of poisoning from the mixture, resulting in at least one death. [4] [5] [6] [7]
A Murphy drip apparatus [1]. A Murphy drip is a rectal infusion apparatus to administer the medical procedure of proctoclysis, also known as rectoclysis. [2] [3] During the procedure, an end of the Murphy drip is inserted into the rectum and large quantities of liquid are infused into the rectum drop by drop. [4]
Although the skin is a large and logical target for drug delivery, its basic functions limit its utility for this purpose. The skin functions mainly to protect the body from external penetration (by e.g. harmful substances and microorganisms) and to contain all body fluids.
Biopharmaceuticals have to be given by injection or infusion. However, recent research found various ways to improve oral bioavailability of these drugs. In particular permeation enhancers, [ 27 ] ionic liquids , [ 28 ] lipid-based nanocarriers, [ 29 ] enzyme inhibitors and microneedles [ 30 ] have shown potential.
A medical professional administering nose drops Instillation of eye drops. A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. [1]
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