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Basic structure of a peroxisome Distribution of peroxisomes (white) in HEK 293 cells during mitosis Peroxisome in rat neonatal cardiomyocyte. A peroxisome (/ p ə ˈ r ɒ k s ɪ ˌ s oʊ m /) [1] is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. [2] [3] Peroxisomes are oxidative ...
A peroxisome is a type of microbody that functions to help the body break down large molecules and detoxify hazardous substances. It contains enzymes like oxidase, react hydrogen peroxide as a byproduct of its enzymatic reactions. Within the peroxisome, hydrogen peroxide can then be converted to water by enzymes like catalase and peroxidase.
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All peroxisomal proteins are synthesized in the cytoplasm and must be directed to the peroxisome. [2] The first step in this process is the binding of the protein to a receptor. The receptor then directs the complex to the peroxisome. Receptors recognize and bind to a region of the peroxisomal protein called a peroxisomal targeting signal, or PTS.
Peroxisome biogenesis factor 1, also known as PEX1, is a protein which in humans is encoded by the PEX1 gene. [ 5 ] This gene encodes a member of the AAA protein family, a large group of ATPases associated with diverse cellular activities.
72129 Ensembl ENSG00000162928 ENSMUSG00000020283 UniProt Q92968 Q9D0K1 RefSeq (mRNA) NM_002618 NM_023651 RefSeq (protein) NP_002609 NP_076140 Location (UCSC) Chr 2: 61.02 – 61.05 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene. It located on chromosome 2 next to KIAA1841 Interactions ...
PPAR-α is primarily activated through ligand binding. Endogenous ligands include fatty acids such as arachidonic acid as well as other polyunsaturated fatty acids and various fatty acid-derived compounds such as certain members of the 15-hydroxyeicosatetraenoic acid family of arachidonic acid metabolites, e.g. 15(S)-HETE, 15(R)-HETE, and 15(S)-HpETE and 13-hydroxyoctadecadienoic acid, a ...
Peroxisome biogenesis factor 10 is a protein that in humans is encoded by the PEX10 gene. [ 5 ] [ 6 ] Alternative splicing results in two transcript variants encoding different isoforms. Function