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Salbutamol/budesonide, sold under the brand name Airsupra, is a fixed-dose combination medication for the treatment of bronchoconstriction and asthma. [ 1 ] [ 2 ] It is a combination of salbutamol sulfate (albuterol sulfate), a short-acting beta2-adrenergic agonist , and budesonide , an inhaled corticosteroid .
Salbutamol is the international nonproprietary name (INN) while albuterol is the United States Adopted Name (USAN). [36] The drug is usually manufactured and distributed as the sulfate salt (salbutamol sulfate). It was first sold by Allen & Hanburys (UK) under the brand name Ventolin, and has been used for the treatment of asthma ever since. [37]
Budesonide, sold under the brand name Pulmicort, among others, is a steroid medication. [8] It is available as an inhaler , nebulization solution , pill , nasal spray , and rectal forms . [ 8 ] [ 9 ] The inhaled form is used in the long-term management of asthma and chronic obstructive pulmonary disease (COPD).
In the mid-1960s, albuterol or salbutamol was discovered, followed by tributalin and fenoterol a few years later. Albuterol and terbutaline gave fewer side effects, such as increased heart rate, than isoproterenol. The pharmaceutical company Glaxo discovered salmeterol, a long-acting β 2-agonist that had bronchodilation activity for up to 12 ...
Formoterol has an extended duration of action (up to 12 h) compared to short-acting β 2 agonists such as salbutamol (albuterol), which are effective for 4 h to 6 h. Formoterol has a relatively rapid onset of action compared to other LABAs, and is effective within 2-3 minutes. [ 2 ]
Inhaled short-acting β2-adrenergic agonists, such as terbutaline and salbutamol, are the first-line drugs indicated for asthma exacerbation for all patients to provide rapid bronchodilating effects. [ 1 ] [ 2 ] Short-acting β2-adrenergic agonists can be delivered by different devices, for example, nebulizers and metered-dose inhalers .
ATC code R03 Drugs for obstructive airway diseases is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
A bronchodilator or broncholytic [1] (although the latter occasionally includes secretory inhibition as well) is a substance that dilates the bronchi and bronchioles, decreasing resistance in the respiratory airway and increasing airflow to the lungs.
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