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In coeliac disease, anti-actin antibody levels correlate with the level of intestinal damage. [2] [3] In autoimmune hepatitis, anti-actin antibody levels correlate with patterns of immune recognition, [4] the pattern of recognition was specific to a small percentage of autoimmune hepatitis type 1 or cryptogenic hepatitis patients. [5]
Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins [5] [6] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of ...
In immunology the particular macromolecule bound by an antibody is referred to as an antigen and the area on an antigen to which the antibody binds is called an epitope. In some cases, an immunoassay may use an antigen to detect for the presence of antibodies, which recognize that antigen, in a solution.
The HOMA model was originally designed as a special case of a more general structural (HOMA-CIGMA) model that includes the continuous infusion of glucose with model assessment (CIGMA) approach; both techniques use mathematical equations to describe the functioning of the major effector organs influencing glucose/insulin interactions.
7114 n/a Ensembl ENSG00000205542 n/a UniProt P62328 n/a RefSeq (mRNA) NM_021109 n/a RefSeq (protein) NP_066932 n/a Location (UCSC) Chr X: 12.98 – 12.98 Mb n/a PubMed search n/a Wikidata View/Edit Human Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene. Recommended INN (International Nonproprietary Name) for thymosin beta-4 is 'timbetasin', as published by the World ...
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits.
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Discovered independently by Benny Geiger [5] and Keith Burridge, [6] its sequence is 20%–30% similar to α-catenin, which serves a similar ...
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils.It is found in essentially all eukaryotic cells, where it may be present at a concentration of over 100 μM; its mass is roughly 42 kDa, with a diameter of 4 to 7 nm.