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The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function, but in different structural forms suitable to the environment they function in. Alkaline phosphatase is found in the periplasmic ...
Function. Alkaline phosphatase, placental type is a membrane-bound glycosylated dimeric enzyme, also referred to as the heat-stable form, that is expressed primarily in the placenta, although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. [7]
H&E stain. Elevated alkaline phosphatase occurs when levels of alkaline phosphatase (ALP) exceed the reference range. This group of enzymes has a low substrate specificity and catalyzes the hydrolysis of phosphate esters in a basic environment. The major function of alkaline phosphatase is transporting chemicals across cell membranes. [1]
Alkaline phosphatase is often elevated in pregnancy due to production from the placenta, but may be additionally elevated. [4] Other abnormalities may include an elevated white blood cell count , hypoglycemia , elevated coagulation parameters, including the international normalized ratio , and decreased fibrinogen .
003436. [edit on Wikidata] Liver function tests (LFTs or LFs), also referred to as a hepatic panel, are groups of blood tests that provide information about the state of a patient's liver. [1] These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin, bilirubin (direct and indirect), and others.
Molar mass. 161 125.18 g·mol −1. Asfotase alfa, sold under the brand name Strensiq, is a medication used in the treatment of people with perinatal /infantile- and juvenile-onset hypophosphatasia. [5][6][7][8][9][10][11] The most common side effects include injection site reactions, hypersensitivity reactions (such as difficulty breathing ...
Alkaline phosphatase allows for mineralization of calcium and phosphorus by bones and teeth. [19] ALPL gene mutation leads to insufficient TNSALP enzyme and allows for an accumulation of chemicals such as inorganic pyrophosphate [19] to indirectly cause elevated calcium levels in the body and lack of bone calcification.
Vanishing bile duct syndrome. Other names. Ductopenia. Specialty. Gastroenterology. Vanishing bile duct syndrome is a loose collection of diseases leading to hepatic bile duct injury and eventual ductopenia. [1]