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Circulating tumor cell. An illustration depicting primary tumor (in the form of tumor microenvironment) and the circulating tumor cells. A circulating tumor cell (CTC) is a cell that has shed into the vasculature or lymphatics [1] from a primary tumor and is carried around the body in the blood circulation. CTCs can extravasate and become seeds ...
The types of statistical methods used in RCTs depend on the characteristics of the data and include: For dichotomous (binary) outcome data, logistic regression (e.g., to predict sustained virological response after receipt of peginterferon alfa-2a for hepatitis C [ 69 ] ) and other methods can be used.
Closed timelike curve. In mathematical physics, a closed timelike curve (CTC) is a world line in a Lorentzian manifold, of a material particle in spacetime, that is "closed", returning to its starting point. This possibility was first discovered by Willem Jacob van Stockum in 1937 [ 1 ] and later confirmed by Kurt Gödel in 1949, [ 2 ] who ...
DNA and RNA codon tables. A codon table can be used to translate a genetic code into a sequence of amino acids. [1][2] The standard genetic code is traditionally represented as an RNA codon table, because when proteins are made in a cell by ribosomes, it is messenger RNA (mRNA) that directs protein synthesis. [2][3] The mRNA sequence is ...
An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells can therefore be grown for prolonged periods in vitro. The mutations required for immortality can occur ...
Circulating tumor DNA (ctDNA) is found in serum and plasma fractions from blood. The mechanism of ctDNA release is unknown, though apoptosis, necrosis, and active secretion from tumor cells have been hypothesized. Once ctDNA is isolated, it can be sequenced for mutational analysis. Circulating tumor DNA (ctDNA) is tumor -derived fragmented DNA ...
CTCF. Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [5][6] CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V (D)J recombination [7] and regulation of chromatin architecture.
Clone (cell biology) A clone is a group of identical cells that share a common ancestry, meaning they are derived from the same cell. [1] Clonality implies the state of a cell or a substance being derived from one source or the other. Thus there are terms like polyclonal —derived from many clones; oligoclonal[2] —derived from a few clones ...