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Rate dependence of the action potential is a fundamental property of cardiac cells and alterations can lead to severe cardiac diseases including cardiac arrhythmia and sometimes sudden death. [3] Action potential activity within the heart can be recorded to produce an electrocardiogram (ECG). This is a series of upward and downward spikes ...
As an action potential (nerve impulse) travels down an axon there is a change in electric polarity across the membrane of the axon. In response to a signal from another neuron, sodium- (Na +) and potassium- (K +)–gated ion channels open and close as the membrane reaches its threshold potential. Na + channels open at the beginning of the ...
Cardiac muscle tissue has autorhythmicity, the unique ability to initiate a cardiac action potential at a fixed rate – spreading the impulse rapidly from cell to cell to trigger the contraction of the entire heart. This autorhythmicity is still modulated by the endocrine and nervous systems. [1]
Image showing the cardiac pacemaker or SA node, the primary pacemaker within the electrical conduction system of the heart. The contraction of cardiac muscle (heart muscle) in all animals is initiated by electrical impulses known as action potentials that in the heart are known as cardiac action potentials. The rate at which these impulses fire ...
An impulse (action potential) that originates from the SA node at a relative rate of 60-100 bpm is known as a normal sinus rhythm. If SA nodal impulses occur at a rate less than 60 bpm, the heart rhythm is known as sinus bradycardia. If SA nodal impulses occur at a rate exceeding 100bpm, the consequent rapid heart rate is sinus tachycardia ...
Pacemaker potential. In the pacemaking cells of the heart (e.g., the sinoatrial node), the pacemaker potential (also called the pacemaker current) is the slow, positive increase in voltage across the cell 's membrane (the membrane potential) that occurs between the end of one action potential and the beginning of the next action potential.
The cardiac transient outward potassium current (referred to as Ito1 or Ito[1] ) is one of the ion currents across the cell membrane of heart muscle cells. It is the main contributing current during the repolarizing phase 1 of the cardiac action potential. It is a result of the movement of positively charged potassium (K +) ions from the ...
Ventricular action potential. The action potential of a ventricular myocyte. In electrocardiography, the ventricular cardiomyocyte membrane potential is about −90 mV at rest, [1] which is close to the potassium reversal potential. When an action potential is generated, the membrane potential rises above this level in five distinct phases.
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