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Doses as high as 15–20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously. [17] In addition to producing PCP-like mental effects, high doses may cause a false-positive result for PCP and opiates in some drug tests. [9] [18]
Chemically, PCP is a member of the arylcyclohexylamine class, and pharmacologically, it is a dissociative anesthetic. [5][10][11] PCP works primarily as an NMDA receptor antagonist. [10] PCP is most commonly used in the United States. [12] While usage peaked in the US in the 1970s, [13] between 2005 and 2011 an increase in visits to emergency ...
Dextromethorphan is the dextrorotatory enantiomer of levomethorphan, which is the methyl ether of levorphanol, both opioid analgesics. It is named according to IUPAC rules as (+)-3-methoxy-17-methyl-9α,13α,14α- morphinan. As its pure form, dextromethorphan occurs as an odorless, opalescent white powder.
Under the new pricing plan, a month’s supply of the lowest dose, 2.5 milligrams, will cost $399, while a month’s supply of the 5 mg dose will cost $549. That’s down from a monthly list price ...
Doctors share why fingers get pruney in water, including causes of wrinkled fingers and toes, treatments, and the theory behind the evolutionary response.
The high affinity of 3-HO-PCP for opioid receptors is unique among arylcyclohexylamines and is in contrast to PCP, which has only very low affinity for the MOR (K i = 11,000–26,000 nM; 282- to 433-fold difference) and the other opioid receptors (K i = 4,100 nM for the KOR and 73,000 nM for the DOR).
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