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"Most studies found that between one to four cups of coffee a day support liver health. ... not only help prevent liver damage, but it could also possibly reverse the effects of a liver injury ...
The health effects of coffee include various possible health benefits and health risks. [1]A 2017 umbrella review of meta-analyses found that drinking coffee is generally safe within usual levels of intake and is more likely to improve health outcomes than to cause harm at doses of 3 or 4 cups of coffee daily.
Researchers analyzed data and found that drinking two additional cups of coffee a day was linked to a 44% lower risk of developing liver cirrhosis.
The popular drink is 'widely accessible and could offer a potential preventative treatment'.
Caffeine can accumulate in individuals with severe liver disease, increasing its half-life. [195] A 2011 review found that increased caffeine intake was associated with a variation in two genes that increase the rate of caffeine catabolism. Subjects who had this mutation on both chromosomes consumed 40 mg more caffeine per day than others. [196]
Reverse tolerance or drug sensitization is a pharmacological phenomenon describing subjects' increased reaction (positive or negative) to a drug following its repeated use. [4] Not all drugs are subject to reverse tolerance. This is the opposite of drug tolerance, in which the effect or the subject's reaction decreases following its repeated ...
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