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Lexapro is one of the most recognizable drug names of our modern era. Escitalopram, a less recognizable term, is the generic name for this common prescription antidepressant.
Lexapro, for example, is also commonly associated with brain zaps—but just because you take one of these meds does not mean you’re guaranteed to develop the side effect when you stop taking it.
Illustration showing the hepatic portal vein system. The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.
Antidepressants are a class of medications used very commonly to treat depression. In fact, nearly 13 percent of people 12 and over in the U.S. used antidepressants in 2017, according to the ...
Escitalopram, sold under the brand names Lexapro and Cipralex, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [9] Escitalopram is mainly used to treat major depressive disorder and generalized anxiety disorder. [9] It is taken by mouth, [9] available commercially as an oxalate salt exclusively.
The first of which is that the pro-drug may be able to pass through the barrier and then also re-pass through the barrier without ever releasing the drug in its active form. The second is the sheer size of these types of molecules makes it still difficult to pass through the blood–brain barrier. [11]
As an SSRI, Lexapro works by modifying levels of the neurotransmitter serotonin in your brain and body. Serotonin plays a key role in regulating your moods, including feelings of happiness and ...
The difference in a drug's concentration in arterial blood (before it has circulated around the body) and venous blood (after it has passed through the body's organs) represents the amount of the drug that the body has eliminated or cleared.