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Synthesis of an amide with work-up step in red. A concentrated solution of sodium bicarbonate is added to the reaction mixture. This will promote the migration of impurities and byproducts to the aqueous layer and leave the product in the dichloromethane (organic layer). The aqueous and organic layers are allowed to separate.
Acid–base extraction is a subclass of liquid–liquid extractions and involves the separation of chemical species from other acidic or basic compounds. [1] It is typically performed during the work-up step following a chemical synthesis to purify crude compounds [2] and results in the product being largely free of acidic or basic impurities.
The tert-butyloxycarbonyl protecting group or tert-butoxycarbonyl protecting group [1] (BOC group) is an acid-labile protecting group used in organic synthesis. The BOC group can be added to amines under aqueous conditions using di-tert-butyl dicarbonate in the presence of a base such as sodium hydroxide:
Typically, this will be to extract organic compounds out of an aqueous phase and into an organic phase, but may also include extracting water-soluble impurities from an organic phase into an aqueous phase. [1] [2] Common extractants may be arranged in increasing order of polarity according to the Hildebrand solubility parameter:
A separatory funnel used for liquid–liquid extraction, as evident by the two immiscible liquids.. Liquid–liquid extraction, also known as solvent extraction and partitioning, is a method to separate compounds or metal complexes, based on their relative solubilities in two different immiscible liquids, usually water (polar) and an organic solvent (non-polar).
The aqueous phase is being drained into the beaker. A separatory funnel , also known as a separation funnel , separating funnel , or colloquially sep funnel , is a piece of laboratory glassware used in liquid-liquid extractions to separate ( partition ) the components of a mixture into two immiscible solvent phases of different densities . [ 1 ]
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The resulting mixture is called an acetate buffer, consisting of aqueous CH 3 COOH and aqueous CH 3 COONa. Acetic acid, along with many other weak acids, serve as useful components of buffers in different lab settings, each useful within their own pH range. Ringer's lactate solution is an example where the conjugate base of an organic acid ...