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Fat necrosis may result from various injuries to adipose tissue, including: physical trauma, enzymatic digestion of adipocytes by lipases, [3] radiation therapy, [4] hypoxia, or inflammation of subcutaneous fat (panniculitis). The gross appearance of fat necrosis is as an irregular, chalky white area within otherwise normal adipose tissue. [1]
In the study Children of the 90s, 2.5% born in 1991 and 1992 were found by ultrasound at the age of 18 to have non-alcoholic fatty liver disease; five years later transient elastography found over 20% to have the fatty deposits on the liver, indicating non-alcoholic fatty liver disease; half of those were classified as severe. The scans also ...
Ultrasound presented average sensitivity and specificity for diagnosing the disease in children, while in the adult population, sensitivity and specificity were significantly higher. Proton density fat fraction magnetic resonance imaging has been increasingly used for the diagnosis of steatosis in pediatric patients. [citation needed]
Abdominal ultrasound may show fat deposition in the liver, but, as the hallmark of this condition is microvesicular steatosis (see pathology below), this is not seen on ultrasound. [11] Rarely, the condition can be complicated by rupture or necrosis of the liver, which may be identified by ultrasound. [citation needed]
On ultrasound, fat is more echogenic (capable of reflecting sound waves). The combination of liver steatosis being dark on CT and bright on ultrasound is sometimes known as the flip flop sign. [citation needed] On magnetic resonance imaging, multiecho gradient echo images can be used to determine the percent fat fraction of the liver. [13]
A skin biopsy and the clinical presentation must both be taken into account for the most accurate diagnosis. [11] But in order to prevent skin biopsy, ultrasonography examination has been shown to be useful in identifying the newborn's subcutaneous fat necrosis when combined with Doppler blood flow analysis; this usually indicates a subcutaneous high echo signal, either with or without ...
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These techniques are known as Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) [31] [32] and Ultrasound guided Focused Ultrasound Surgery (USgFUS) respectively. [1] [33] MRgFUS is a 3D imaging technique which features high soft tissue contrast and provides information about temperature, thus allowing to monitor ablation.