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Treatment should take into account the cause and severity of the condition. [6] Treatment is done by vitamin B 12 supplementation, either by mouth or by injection. [3] Initially in high daily doses, followed by less frequent lower doses, as the condition improves. [3] If a reversible cause is found, that cause should be corrected if possible. [11]
The disease can also be caused by inhalation of nitrous oxide, which inactivates vitamin B12. [11] Vitamin E deficiency, which is associated with malabsorption disorders such as cystic fibrosis and Bassen-Kornzweig syndrome, [12] can cause a similar presentation due to the degeneration of the dorsal columns. [5]
Fortunately, though, vitamin B12 isn't so hard to get enough of because it's so widely dispersed in the food supply and daily needs are relatively low. 4 Overlooked Causes of Vitamin B12 ...
Age. The risk of most causes of joint pain increases with age. This may be due to increased wear and stress on joints over time and a higher likelihood of other underlying medical conditions ...
Thus, the discovery of liver juice as a treatment for pernicious anemia had been by coincidence. However, Minot, Murphy, and Whipple received the joint Nobel Prize for discovering a cure for a previously fatal disease of unknown cause in 1934, becoming the first Americans to be awarded the Nobel Prize in Physiology and Medicine. [71] [75]
"Joint pain, like any other pain in the body, is a signal that something may not be working properly in our musculoskeletal system," says Dr. Jeffrey Zarin, MD, an orthopedic surgeon specializing ...
A second major cause is an age-related decline in stomach acid production (achlorhydria), because acid exposure frees protein-bound vitamin. [12] For the same reason, people on long-term antacid therapy, using proton-pump inhibitors , [ 13 ] H 2 blockers or other antacids are at increased risk.
Coxalgia is a symptom of underlying hip joint pathology and must be examined and referred as the symptoms of pain and reduced mobility will increase and worsen, leading to chronic pain states. Coxalgia may be due to trauma, dysplasia and abnormal growth, degeneration, osteo-deficiencies of B12 or folate or metastasising cancer. Pain management ...
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