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2. Vitamin D receptor - Wikipedia

   en.wikipedia.org/wiki/Vitamin_D_receptor

   In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13.11. [7] VDR is expressed in most tissues of the body, and regulates transcription of genes involved in intestinal and renal transport of calcium and other minerals. [8] Glucocorticoids decrease VDR expression. [8] Many types of immune cells also express VDR ...

3. VDRE - Wikipedia

   en.wikipedia.org/wiki/VDRE

   The VDR is widely distributed in tissues, and is not restricted to those tissues considered the classic targets of vitamin D. The VDR upon binding to 1,25(OH) 2 D heterodimerizes with other nuclear hormone receptors, in particular the family of retinoid X receptors. This VDR/RXR heterodimer complex binds to the specific VDRE in the promoters of ...

4. Vitamin D - Wikipedia

   en.wikipedia.org/wiki/Vitamin_D

   The VDR/RXR complex subsequently binds to vitamin D response elements (VDRE) which are specific DNA sequences adjacent to genes, numbers estimated as being in the thousands. The VDR/RXR/DNA complex recruits other proteins that transcribe the downstream gene into mRNA which in turn is translated into protein causing a change in cell function. [3 ...

5. Vitamin D deficiency - Wikipedia

   en.wikipedia.org/wiki/Vitamin_D_deficiency

   Serum level of 25(OH)D is the laboratory test ordered to indicate whether or not a person has vitamin D deficiency or insufficiency. [53] It is also considered reasonable to treat at-risk persons with vitamin D supplementation without checking the level of 25(OH)D in the serum, as vitamin D toxicity has only been rarely reported to occur. [53]

6. Genetic testing - Wikipedia

   en.wikipedia.org/wiki/Genetic_testing

   Genetic testing is often done as part of a genetic consultation and as of mid-2008 there were more than 1,200 clinically applicable genetic tests available. [23] Once a person decides to proceed with genetic testing, a medical geneticist, genetic counselor, primary care doctor, or specialist can order the test after obtaining informed consent .

7. V (D)J recombination - Wikipedia

   en.wikipedia.org/wiki/V(D)J_recombination

   The light chain genes possess either a single (Cκ) or four (Cλ) Constant gene segments with numerous V and J gene segments but do not have D gene segments. [3] DNA rearrangement causes one copy of each type of gene segment to go in any given lymphocyte, generating an enormous antibody repertoire; roughly 3×10 11 combinations are possible ...