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The period of relaxation that occurs as the chambers fill with blood is called diastole. Both the atria and ventricles undergo systole and diastole, and it is essential that these components be carefully regulated and coordinated to ensure blood is pumped efficiently to the body. [1] The cardiac cycle as correlated to the ECG
Diastole (/ d aɪ ˈ æ s t ə l i / dy-AST-ə-lee) is the relaxed phase of the cardiac cycle when the chambers of the heart are refilling with blood. The contrasting phase is systole when the heart chambers are contracting. Atrial diastole is the relaxing of the atria, and ventricular diastole the relaxing of the ventricles.
A Wiggers diagram modified from [1]. A Wiggers diagram, named after its developer, Carl Wiggers, is a unique diagram that has been used in teaching cardiac physiology for more than a century.
At this point, the atrial systole applies contraction pressure to 'topping-off' the blood volumes sent to both ventricles; this atrial contraction closes the diastole immediately before the heart again begins contracting and ejecting blood from the ventricles (ventricular systole) to the aorta and arteries.
As diastole ends, the ventricles begin depolarizing and, while ventricular pressure starts to rise owing to contraction, the atrioventricular valves close in order to prevent backflow to the atria. At this stage, which corresponds to the R peak or the QRS complex seen on an ECG , the semilunar valves ( aortic and pulmonary valves) are also closed .
Pulse pressure is calculated as the difference between the systolic blood pressure and the diastolic blood pressure. [3] [4]The systemic pulse pressure is approximately proportional to stroke volume, or the amount of blood ejected from the left ventricle during systole (pump action) and inversely proportional to the compliance (similar to elasticity) of the aorta.
Blood velocities in arteries are higher during systole than during diastole. One parameter to quantify this difference is the pulsatility index (PI), which is equal to the difference between the peak systolic velocity and the minimum diastolic velocity divided by the mean velocity during the cardiac cycle. This value decreases with distance ...
Diastolic dysfunction is associated with a reduced compliance, or increased stiffness, of the ventricle wall. This reduced compliance results in an inadequate filling of the ventricle and a decrease in the end-diastolic volume. The decreased end-diastolic volume then leads to a reduction in stroke volume because of the Frank-Starling mechanism. [1]
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