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Top: An ancestral gene duplication produces two paralogs (histone H1.1 and 1.2). A speciation event produces orthologs in the two daughter species (human and chimpanzee). Bottom: in a separate species , a gene has a similar function (histone-like nucleoid-structuring protein) but has a separate evolutionary origin and so is an analog.
The PER1 ortholog was first discovered by Ronald Konopka and Seymour Benzer in 1971. During 1997, Period 1 (mPer1) and Period 2 (mPer2) genes were discovered (Sun et al., 1997 and Albretch et al., 1997). Through homology screens with the Drosophila per, these genes were discovered.
In the fruitfly Drosophila, irradiation of germ line cells generates double-strand breaks that result in cell cycle arrest and apoptosis. The Drosophila CHEK2 ortholog mnk and the p53 ortholog dp53 are required for much of the cell death observed in early oogenesis when oocyte selection and meiotic recombination occur.
126248 384605 Ensembl ENSG00000166359 ENSMUSG00000118454 UniProt Q6ZMY6 n/a RefSeq (mRNA) NM_173479 NM_001370886 RefSeq (protein) NP_775750 n/a Location (UCSC) Chr 19: 33.13 – 33.18 Mb Chr 7: 34.94 – 34.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse WDR88 (WD repeat containing protein 88) is a protein, which in humans, is encoded by the gene WDR88. It consists of seven WD40 ...
Whether homologous recombination or NHEJ is used to repair double-strand breaks is largely determined by the phase of cell cycle. Homologous recombination repairs DNA before the cell enters mitosis (M phase). It occurs during and shortly after DNA replication, in the S and G 2 phases of the cell cycle, when sister chromatids are more easily ...
Fig. 1 The diagram shows the role of Cdk1 in progression through the S. cerevisiae cell cycle. Cln3-Cdk1 leads to Cln1,2-Cdk1 activity, eventually resulting in Clb5,6-Cdk1 activity and then Clb1-4-Cdk1 activity. [5] When bound to its cyclin partners, Cdk1 phosphorylation leads to cell cycle progression.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells.
Figure 1: Schematic of the cell cycle. outer ring: I = Interphase, M = Mitosis; inner ring: M = Mitosis, G 1 = Gap 1, G 2 = Gap 2, S = Synthesis; not in ring: G 0 = Gap 0/Resting. Replication timing refers to the order in which segments of DNA along the length of a chromosome are duplicated.