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Contrarily stronger stimulation protocols are needed to recruit L-LTP that begins after a few hours, lasts for at least eight hours, and depends on the activation of de novo gene transcription. These different characteristics suggest a relationship between E-LTP and short-term memory phase, as well as L-LTP and long-term memory phase. [1]
Abnormal accumulation of tau protein, which constitutes neurofibrillary tangles, in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer's disease at Braak stage VI. The bar = 25 microns (0.025 millimeters). Staging in Alzheimer's disease was described by Braak in 1991. [8]
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy : a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain . [ 1 ]
It is believed that the new technology will provide not only future early diagnosis of Alzheimer's disease but also possible therapy for Alzheimer's disease. An open international study group (ND.Neuromark.net) has been constituted for arranging scientific information and developing a rational guide for implementing biomarkers into routine ...
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
Vascular dementia; The misfolding of proteins is a common component of the proposed pathophysiology of many aging-related diseases. However, there is insufficient evidence to prove this. For example, the tau hypothesis for Alzheimer's proposes that tau protein accumulation results in the breakdown of neuron cytoskeletons, leading to Alzheimer's ...
Brain Aβ is elevated in people with sporadic Alzheimer's disease. Aβ is the main constituent of brain parenchymal and vascular amyloid; it contributes to cerebrovascular lesions and is neurotoxic. [ 33 ] [ 34 ] [ 35 ] It is unresolved how Aβ accumulates in the central nervous system and subsequently initiates the disease of cells.
Zhenyu Yue's research has primarily concentrated on the molecular and cellular mechanisms underlying neurodegenerative diseases, with a particular focus on Parkinson’s disease and Alzheimer’s disease. [9] One of the notable areas of Yue's research involves the study of autophagy, a cellular process that degrades and recycles cellular ...
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