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The term long-term potentiation comes from the fact that this increase in synaptic strength, or potentiation, lasts a very long time compared to other processes that affect synaptic strength. [ 1 ] In neuroscience , long-term potentiation ( LTP ) is a persistent strengthening of synapses based on recent patterns of activity.
In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.
The basic BCM rule takes the form = (()) (),where: is the synaptic weight of the th synapse,; is th synapse's input current, = () = () is the inner product of weights and input currents (weighted sum of inputs),
Early long-term potentiation (E-LTP) is the first phase of long-term potentiation (LTP), a well-studied form of synaptic plasticity, and consists of an increase in synaptic strength. [1] LTP could be produced by repetitive stimulation of the presynaptic terminals, and it is believed to play a role in memory function in the hippocampus, amygdala ...
Spike-timing-dependent plasticity (STDP) is a biological process that adjusts the strength of connections between neurons in the brain.The process adjusts the connection strengths based on the relative timing of a particular neuron's output and input action potentials (or spikes).
In other words, whenever homosynaptic long-term potentiation is induced at a given synapse, other unstimulated synapses should be depressed. [2] Conversely, homosynaptic long-term depression would cause other synapses to potentiate in a manner which keeps the average synaptic weight approximately conserved. The scope of these changes could be ...
Long-term potentiation (neurophysiology), a long-lasting enhancement in signal transmission between neurons 'The All-Species Living Tree' Project , a project to create a phylogeny of all Bacteria and Archaea
The theory was validated in part by the discovery of long-term potentiation. Studies of LTP on multiple presynaptic cells stimulating a postsynaptic cell uncovered the property of associativity. A weak neuronal stimulation onto a pyramidal neuron may not induce long-term potentiation.