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Malassezia is a genus of fungi (specifically, a yeast). Some species of Malassezia are found on the skin of animals, including humans. Because malassezia requires fat to grow, [3] it is most common in areas with many sebaceous glands—on the scalp, [4] face, and upper part of the body.
Malassezia furfur (formerly known as Pityrosporum ovale) is a species of yeast (a type of fungus) that is naturally found on the skin surfaces of humans and some other mammals. It is associated with a variety of dermatological conditions caused by fungal infections , notably seborrhoeic dermatitis and tinea versicolor .
Malassezia pachydermatis is a bottle-shaped, [2] non-lipid dependent lipophilic yeast in the genus Malassezia. [5] Colonies are cream or yellowish in colour, smooth to wrinkled and convex with a margin possessing a slightly lobed appearance. [5] [8] Cells are ovoidal in shape and range in size from 3.0–6.5 x 2.5 μm. [5]
It is considered to be part of the skin's normal human microbiota [2] [6] and begins to colonize the skin of humans shortly after birth. [7] Malassezia sympodialis, often has a symbiotic or commensal relationship with its host, but it can act as a pathogen causing a number of different skin diseases, [8] such as atopic dermatitis. [8] [9]
Identification of Malassezia on skin has been aided by the application of molecular or DNA-based techniques. These investigations show that the Malassezia species causing most skin disease in humans, including the most common cause of dandruff and seborrhoeic dermatitis, is M. globosa (though M. restricta is also involved). [1]
The majority of tinea versicolor is caused by the fungus Malassezia globosa, although Malassezia furfur is responsible for a small number of cases. [ 2 ] [ 3 ] These yeasts are normally found on the human skin and become troublesome only under certain conditions, such as a warm and humid environment, although the exact conditions that cause ...
Species of Malassezia implicated in Seborrhoeic dermatitis include M. furfur (formerly Pityrosporum ovale), M. globosa, M. restricta, M. sympodialis, and M. slooffiae. [ 3 ] Malassezia appears to be the significant factor in seborrhoeic dermatitis but it is thought that other factors are necessary for the presence of Malassezia to result in the ...
Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema. [2] Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff. [2]
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