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The U.S. Food and Drug Administration recommends precaution about using dietary supplements because some products may not be risk free under certain circumstances or may interact with prescription and over-the-counter medicines. [40] As with any herbal preparation, individual doses of Echinacea may vary significantly in chemical composition. [31]
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...
Every medication has potential adverse side-effects. With every drug added, there is an additive risk of side-effects. Also, some medications have interactions with other substances, including foods, other medications, and herbal supplements. [46] 15% of older adults are potentially at risk for a major drug-drug interaction. [47]
Saw palmetto extract has interactions with other medications. [3] When used in combination with an anticoagulant or anti-platelet drug, saw palmetto extract can increase the risk of bleeding by enhancing the anticoagulation or anti-platelet effects. [3]
Pygeum mooneyi Raiz. Prunus pygeoides , ( Chinese : 云南桂樱 "Yunnan cherry laurel"), is a species of Prunus native to India and China, preferring to grow at 900–1500 m. It is typically a tree reaching 6-10 m tall.
This phenomenon can also be observed in adults who use the medication as a sleep aid. The prevalence of this paradoxical reaction is unknown, but research into the phenomenon suggests that it may be as a result of the medicine's interactions with the CYP2D6 enzyme , and that a metabolite of diphenhydramine may be to blame.
The extract Pygeum is an herbal remedy prepared from the bark of P. africana and is promoted as an alternative medicine for benign prostatic hyperplasia (BPH). [25] A 2016 literature review found that Pygeum offered no benefit. [26] A 2019 review said it showed some evidence of BPH symptom relief. [27] [need quotation to verify]
The use of sedating drugs alongside hydroxyzine can cause oversedation and confusion if administered at high doses—any form of hydroxyzine treatment alongside sedatives should be done under the supervision of a doctor. [28] [25] Because of the potential for more severe side effects, this drug is on the list to avoid in the elderly. [29]
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