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Kidney stone disease, also known as renal calculus disease, nephrolithiasis or urolithiasis, is a crystallopathy where a solid piece of material (renal calculus) develops in the urinary tract. [2] Renal calculi typically form in the kidney and leave the body in the urine stream. [2] A small calculus may pass without causing symptoms. [2]
Nephrolithiasis is the medical term employing kidney stone formation. The increased saturation of urine with calcium elevates the rate of stone formation within the kidneys, due to the excess calcium precipitating and forming crystals, which develop into larger stones over time. [ 23 ]
Nausea and vomiting may also occur. An obstruction that occurs at the urethra or bladder outlet can cause pain and pressure resulting from distension of the bladder. Blocking the flow of urine will commonly be prone to urinary tract infections which can lead to further development of stones, fever, and blood or pus in the urine.
Other symptoms include cardiac arrhythmias (especially in those taking digoxin), fatigue, nausea, vomiting (emesis), loss of appetite, abdominal pain, & paralytic ileus. If kidney impairment occurs as a result, manifestations can include increased urination, urination at night, and increased thirst. [6]
Symptoms most often include fever and flank tenderness. [2] Other symptoms may include nausea, burning with urination, and frequent urination. [2] Complications may include pus around the kidney, sepsis, or kidney failure. [3] It is typically due to a bacterial infection, most commonly Escherichia coli. [2]
Nausea. Vomiting. Constipation. Loss of appetite. Dehydration. Confusion. Kidney stones "In extreme cases, vitamin D toxicity can cause kidney failure, cardiac arrhythmias and even death," says ...
The predominant symptoms of hypercalcemia are abdominal pain, constipation, extreme thirst, excessive urination, kidney stones, nausea and vomiting. [ 3 ] [ 14 ] In severe cases where the calcium concentration is >14 mg/dL, individuals may experience confusion, altered mental status, coma, and seizure.
Black and white women aged 70–79 have the highest overall prevalence. [62] Secondary hyperparathyroidism is most commonly caused by chronic kidney disease and vitamin D deficiency. [63] The prevalence of vitamin D deficiency is about 50% of the world population and chronic kidney disease prevalence is 15% of the United States population. [51]
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