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The thalidomide molecule is a synthetic derivative of glutamic acid and consists of a glutarimide ring and a phthaloyl ring (Figure 5). [15] [16] Its IUPAC name is 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione and it has one chiral center [15] After thalidomide's selective inhibition of TNF-α had been reported, a renewed effort was put in thalidomide's clinical development.
Pomalidomide, sold under the brand names Pomalyst and Imnovid, [7] [8] is an anti-cancer medication used for the treatment of multiple myeloma and AIDS-related Kaposi sarcoma. [ 7 ] Pomalidomide was approved for medical use in the United States in February 2013, [ 10 ] and in the European Union in August 2013. [ 8 ]
The Confusion Assessment Method (CAM) is a diagnostic tool developed to allow physicians and nurses to identify delirium in the healthcare setting. [1] It was designed to be brief (less than 5 minutes to perform) and based on criteria from the third edition-revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R) .
A common symptom of PTA is confusion. The most prominent symptom of post-traumatic amnesia (PTA) is a loss of memory of the present time. [10] As a result, patients are often unaware of their condition and may behave as if they are going about their regular lives.
Authors report resting metabolism in this area is associated with performance on short-term memory tasks. [14] While post-treatment studies suggest significant negative side effects of chemotherapy on cognition, other studies have indicated that there may be baseline vulnerability factors which could contribute to cognitive impairment development.
An altered level of consciousness can result from a variety of factors, including alterations in the chemical environment of the brain (e.g. exposure to poisons or intoxicants), insufficient oxygen or blood flow in the brain, and excessive pressure within the skull. Prolonged unconsciousness is understood to be a sign of a medical emergency. [3]
The varying effects of stress on performance or stress hormones are often compared to or known as "inverted-u" [10] which induce areas in learning, memory and plasticity. [8] Chronic stress can affect the brain structure and cognition.
In psychology, the misattribution of memory or source misattribution is the misidentification of the origin of a memory by the person making the memory recall.Misattribution is likely to occur when individuals are unable to monitor and control the influence of their attitudes, toward their judgments, at the time of retrieval. [1]