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M72/AS01 E is an experimental tuberculosis vaccine. If approved, it would be the first vaccine for tuberculosis in more than a century after the BCG vaccine. [1] [2] The vaccine consists of two main ingredients. The antigen part is M72, a recombinant fusion protein derived from the sequences of two M. tuberculosis antigens (Mtb32A and Mtb39A ).
Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch . [ 1 ] As of 2021, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921.
The MTBVAC clinical development started with a first-in-human study in healthy adult volunteers in Lausanne, Switzerland (NCT02013245); [12] followed by one additional Phase 1 study in healthy newborns in South Africa in collaboration with South African TuBerculosis Vaccine Initiative (SATVI) (NCT02729571) [13] to corroborate the safety and ...
Non-significant vaccine efficacy was measured at 17.3% (95% CI -31. 9% to 48. 2%) at study completion. The vaccine candidate also did not provide statistically significant protection from ...
The only vaccine, called the BCG vaccine, is used mainly in high-risk areas to protect babies from one form of the disease. Century-old TB vaccine may work better if given in a new way Skip to ...
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MVA85A (modified vaccinia Ankara 85A) is a vaccine against tuberculosis developed by researchers led by Professor Helen McShane at Oxford University. [1] It is a viral vector vaccine and consists of an MVA virus engineered to express the 85A antigen once it infects a host cell. 85A is a cell-wall protein of the tuberculosis bacillus.
The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). [9] It is named after its inventors Albert Calmette and Camille Guérin. [10] [11] In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible. [9]