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Clonidine has some role in the treatment of spasticity caused by spinal cord injury, acting principally by inhibiting excessive sensory transmission below the level of injury [clarify]. Its use, however, is mainly as a second or third line agent, due to side effects such as hypotension, bradycardia, and drowsiness. [42]
Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
However, there is controversy regarding naloxone's efficacy in treating the symptoms of clonidine overdose, namely slow heart rate, low blood pressure, and confusion/somnolence. [28] Case reports that used doses of 0.1 mg/kg (maximum of 2 mg/dose) repeated every 1–2 minutes (10 mg total dose) have shown inconsistent benefit. [28]
But the largest study done yet by J&J of the effects of long-term Risperdal use among children and adolescents—in which, according to the study’s protocol, “special attention” was paid to prolactin—had now found that of 319 children, including 266 males, 8.6 percent of the males had developed gynecomastia, or breasts.
clonidine can be used for ADHD treatment and tics treatment in children(Dr Hussein Abdeldayem , Alex, Egypt) I was prescribed clonidine specifically for my mild Tourette's syndrome, and it works very well. VCUchem 03:28, 10 April 2007 (UTC) My son, 4.5 years old, has been on clonidine for two week to treat ADD, his prescription is 0.05mg.
Bradycardia; Hypertension (high blood pressure); Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema) Anaphylaxis; Changes in appetite
Brimonidine is an α 2 adrenergic agonist. [4]Peripheral α 2 agonist activity results in vasoconstriction of blood vessels (as opposed to central α 2 agonist activity that decreases sympathetic tone, as can be seen by the medication clonidine).
Beneficial side effects are less common; some examples, in many cases of side-effects that ultimately gained regulatory approval as intended effects, are: Bevacizumab ( Avastin ), used to slow the growth of blood vessels, has been used against dry age-related macular degeneration , as well as macular edema from diseases such as diabetic ...
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