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  2. Renal physiology - Wikipedia

    en.wikipedia.org/wiki/Renal_physiology

    Outside the range of pH that is compatible with life, proteins are denatured and digested, enzymes lose their ability to function, and the body is unable to sustain itself. The kidneys maintain acid-base homeostasis by regulating the pH of the blood plasma. Gains and losses of acid and base must be balanced.

  3. Renal compensation - Wikipedia

    en.wikipedia.org/wiki/Renal_compensation

    Renal compensation is a mechanism by which the kidneys can regulate the plasma pH. It is slower than respiratory compensation, but has a greater ability to restore normal values. Kidneys maintain the acid-base balance through two mechanisms: (1) the secretion of H + ions into the urine (from the blood) and (2) the reabsorption of bicarbonate ...

  4. Kidney - Wikipedia

    en.wikipedia.org/wiki/Kidney

    The two organ systems that help regulate the body's acid–base balance are the kidneys and lungs. Acid–base homeostasis is the maintenance of pH around a value of 7.4. The lungs are the part of respiratory system which helps to maintain acid–base homeostasis by regulating carbon dioxide (CO 2) concentration in the blood. The respiratory ...

  5. Bicarbonate buffer system - Wikipedia

    en.wikipedia.org/wiki/Bicarbonate_buffer_system

    As calculated by the Henderson–Hasselbalch equation, in order to maintain a normal pH of 7.4 in the blood (whereby the pK a of carbonic acid is 6.1 at physiological temperature), a 20:1 ratio of bicarbonate to carbonic acid must constantly be maintained; this homeostasis is mainly mediated by pH sensors in the medulla oblongata of the brain ...

  6. Mammalian kidney - Wikipedia

    en.wikipedia.org/wiki/Mammalian_kidney

    The kidneys play a key role in maintaining a constant level of acid-base balance in mammals. [30] In the glomeruli, HCO 3 − is completely filtered into primary urine. [149] To maintain a constant pH, the kidneys reabsorb almost all of the HCO 3 − from primary urine back into the bloodstream and secrete H + into the urine, oxidizing the ...

  7. Osmoregulation - Wikipedia

    en.wikipedia.org/wiki/Osmoregulation

    Osmoregulation is the active regulation of the osmotic pressure of an organism's body fluids, detected by osmoreceptors, to maintain the homeostasis of the organism's water content; that is, it maintains the fluid balance and the concentration of electrolytes (salts in solution which in this case is represented by body fluid) to keep the body fluids from becoming too diluted or concentrated.

  8. Kidney (vertebrates) - Wikipedia

    en.wikipedia.org/wiki/Kidney_(vertebrates)

    The kidneys are a pair of organs of the excretory system in vertebrates, which maintain the balance of water and electrolytes in the body (osmoregulation), filter the blood, remove metabolic waste products, and, in many vertebrates, also produce hormones (in particular, renin) and maintain blood pressure.

  9. Acid–base homeostasis - Wikipedia

    en.wikipedia.org/wiki/Acid–base_homeostasis

    Acid–base homeostasis is the homeostatic regulation of the pH of the body's extracellular fluid (ECF). [1] The proper balance between the acids and bases (i.e. the pH) in the ECF is crucial for the normal physiology of the body—and for cellular metabolism . [ 1 ]