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Levothyroxine, also known as L-thyroxine, is a synthetic form of the thyroid hormone thyroxine (T 4). [ 5 ] [ 8 ] It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma . [ 5 ]
The team behind the recent study had previously shown that levothyroxine use, particularly in people it is used in unnecessarily, can have an array of unwanted side effects.
For patients taking levothyroxine, TSH may be boosted by discontinuing levothyroxine for 3–6 weeks. [5] This long period of hormone withdrawal is required because of levothyroxine's relatively long biological half-life, and may result in symptoms of hypothyroidism in the patient. The shorter half-life of liothyronine permits a withdrawal ...
Effects [ edit ] Drug discontinuation may cause rebound effects (return of the symptoms the drug relieved, and that, to a degree stronger than they were before treatment first began) and withdrawal syndromes (symptoms caused by the discontinuation by the drug itself).
Adding liothyronine to levothyroxine has been suggested as a measure to provide better symptom control, but this has not been confirmed by studies. [9] [15] [65] In 2007, the British Thyroid Association stated that combined T 4 and T 3 therapy carried a higher rate of side effects and no benefit over T 4 alone.
The onset of anti-thyroid effect is rapid but the onset of clinical effects on thyroid hormone levels in the blood is much slower. This is because the large store of pre-formed T 3 and T 4 in the thyroid gland and bound to thyroid binding globulin (99% bound) has to be depleted before any beneficial clinical effect occurs.
Levothyroxine sodium has a sodium salt added to increase the gastrointestinal absorption of levothyroxine. [69] Levothyroxine is preferred over Liothyronine due to its long half-life [ 23 ] leading to stable thyroid hormone levels, [ 70 ] ease of monitoring, [ 70 ] excellent safety [ 70 ] [ 71 ] and efficacy record, [ 67 ] and usefulness in ...
It is used to treat hypothyroidism, [1] but less preferred than levothyroxine. [1] It is taken by mouth. [1] Maximal effects may take up to three weeks to occur. [1] Side effects may occur from excessive doses. [1] This may include weight loss, fever, headache, anxiety, trouble sleeping, arrhythmias, and heart failure. [1]
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