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  2. Alcohol-related brain damage - Wikipedia

    en.wikipedia.org/wiki/Alcohol-related_brain_damage

    Alcohol-related brain damage [1] [2] alters both the structure and function of the brain as a result of the direct neurotoxic effects of alcohol intoxication or acute alcohol withdrawal. Increased alcohol intake is associated with damage to brain regions including the frontal lobe , [ 3 ] limbic system , and cerebellum , [ 4 ] with widespread ...

  3. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. [ 1 ] Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 2 ]

  4. Long-term depression - Wikipedia

    en.wikipedia.org/wiki/Long-term_depression

    In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.

  5. Depression is likely not caused by a chemical imbalance in ...

    www.aol.com/depression-likely-not-caused...

    For years, a chemical imbalance of serotonin has been widely viewed as the culprit for depression, resulting in the widespread use of antidepressants. The study published this week in the journal…

  6. Kindling (sedative–hypnotic withdrawal) - Wikipedia

    en.wikipedia.org/wiki/Kindling_(sedative...

    This progressively lowers the threshold needed to cause alcohol-related brain damage and cognitive impairments, leading to altered neurological function. The changes in activity of excitatory and inhibitory neurotransmitter systems is similar to that which occurs in individuals suffering from limbic or temporal lobe epilepsy. [5]

  7. Depression (mood) - Wikipedia

    en.wikipedia.org/wiki/Depression_(mood)

    Researchers theorized that depression was caused by a chemical imbalance in neurotransmitters in the brain, a theory based on observations made in the 1950s of the effects of reserpine and isoniazid in altering monoamine neurotransmitter levels and affecting depressive symptoms. [90]

  8. Major depressive episode - Wikipedia

    en.wikipedia.org/wiki/Major_depressive_episode

    Despite its longstanding prominence in pharmaceutical advertising, the idea that low serotonin levels cause depression is not supported by scientific evidence. [12] [13] [14] One interpretation is that depression manifests due to an imbalance of neurotransmitters in the brain, resulting in

  9. Endogenous depression - Wikipedia

    en.wikipedia.org/wiki/Endogenous_depression

    Endogenous depression is an atypical subclass of major depressive disorder (clinical depression). It could be caused by genetic and biological factors. [ 1 ] Endogenous depression occurs due to the presence of an internal (cognitive, biological) stressor instead of an external (social, environmental) stressor. [ 2 ]

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