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Pyoderma gangrenosum. There are two main types of pyoderma gangrenosum: [1] the 'typical' ulcerative form, which occurs in the legs; an 'atypical' form that is more superficial and occurs in the hands and other parts of the body; Other variations are: [4] Peristomal pyoderma gangrenosum comprises 15% of all cases of pyoderma; Bullous pyoderma ...
The inflammation and ulceration that occurs as a result of pathergy in pyoderma gangrenosum often responds to systemic steroid therapy. The pathergy reaction is a unique feature of Behçet's disease and, according to the International Study Group for Behcet's Disease, is among the major criteria required for the diagnosis.
Pyoderma gangrenosum is variably expressed, which means that it is not always present in all individuals with the disease. It presents as poorly healing ulcers with undermined edges. Pathergy is an important feature (this term refers to the tendency of ulcers to arise at points of injury).
Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial infections such as impetigo , impetigo contagiosa , ecthyma , folliculitis , Bockhart's impetigo , furuncle , carbuncle , tropical ulcer , etc. [ 1 ] [ 2 ] Autoimmune conditions include pyoderma gangrenosum .
Treatment is typically to avoid the ulcer getting infected, remove any excess discharge, maintain a moist wound environment, control the edema, and ease pain caused by nerve and tissue damage. Topical antibiotics are normally used to prevent the ulcer getting infected, and the wound or ulcer is usually kept clear of dead tissue through surgical ...
Negative pressure wound therapy (NPWT) is a treatment that improves ischemic tissues and removes wound fluid used by bacteria. [8] [14] This therapy, also known as vacuum-assisted closure, reduces swelling in tissues, which brings more blood and nutrients to the area, as does the negative pressure itself. [8] The treatment also decompresses ...
Additional causes include neutrophilic skin conditions such as pyoderma gangrenosum or Sweet's syndrome; vasculitic processes such as cryoglobulinemia; calciphylaxis (often seen in people with end-stage kidney disease but may also occur with medications such as warfarin); cancers such as squamous cell carcinoma (Marjolin's ulcer) or ...
In modern typical usage, the solution is applied to the wound once daily for lightly to moderately exudative wounds, and twice daily for heavily exudative wounds or highly contaminated wounds. [ 3 ] The healthy skin surrounding the wound should preferably be protected with a moisture barrier ointment (e.g., petroleum jelly ) or skin sealant as ...