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HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.
There are three mammalian hyaluronan synthases described to date - HAS1, HAS2, and HAS3. Each of these isoforms resides at a different chromosome location [ 2 ] and has been cloned . [ 3 ] Two of the main differences between the isoforms are the chain length of the hyaluronan molecules that they produce and the ease with which they can be ...
Hyaluronan (-4GlcUAβ1-3GlcNAcβ1-) n. The fourth class of GAG, hyaluronic acid (HA), is not sulfated and is synthesized by three transmembrane synthase proteins HAS1, HAS2, and HAS3. HA, a linear polysaccharide, is composed of repeating disaccharide units of →4)GlcAβ(1→3)GlcNAcβ(1→ and has a very high molecular mass, ranging from 10 5 ...
Hyaluronic acid (/ ˌ h aɪ. ə l j ʊəˈr ɒ n ɪ k /; [1] [2] abbreviated HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.
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On the other hand, some enzymes induce HA production like sucrose-6-phosphatate hydrolase, [27] and hyaluronan synthase. [28] Using combined approaches with these two type enzymes is a good strategy for high yield HA production. [21]
[26] [27] It is a dual vial unit with one vial of immune globulin infusion 10% (human) and one vial of recombinant human hyaluronidase. [12] It is an immune globulin with a recombinant human hyaluronidase indicated in the United States for the treatment of primary immunodeficiency in adults.
Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene. [ 5 ] [ 6 ] Hyaluronan or hyaluronic acid is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix .
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