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Plasma concentration profiles of vutrisiran showed rapid absorption and elimination from systemic circulation. There was a dose-proportional increase in peak plasma concentrations Cmax and a slightly greater than dose-proportional increase in AUC∞ inf and AUC last after a single subcutaneous dose across the dose range studied in the phase I trial in healthy volunteers.
Alnylam (ALNY) submits a marketing authorization application to the EMA for vutrisiran to treat adult patients with polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis.
President-elect Donald Trump notched a 54% approval rating, ... (61%) compared to women ... compared to 48% among those over 70. Notably, his favorability has risen among younger voters, with 55% ...
Winston Churchill is generally considered one of the greatest prime ministers for his leadership during the Second World War. Robert Jenkinson, 2nd Earl of Liverpool, a Tory prime minister from 1812 to 1827, is ranked highly despite being called "the Arch-mediocrity" by later Conservative prime minister Benjamin Disraeli.
Here are links to possibly useful sources of information about Vutrisiran. PubMed provides review articles from the past five years (limit to free review articles ) The TRIP database provides clinical publications about evidence-based medicine .
According to a series of Gallup polls dating back to 1969, former president George W. Bush's wife, Laura Bush, has received the highest approval ratings as first lady in recent U.S. history.
Trump’s final approval rating as president in January 2021 was 29 percent in a Pew Research Center poll. Trump will be sworn in as president on January 20, 2025.
In March 2024, Amylyx Pharmaceuticals announced that its Phase III PHOENIX clinical trial of 664 American and European adults followed over 48 weeks showed no statistically significant difference in the functioning of ALS patients that were randomly assigned to treatment with Relyvrio, as compared to those receiving a placebo drug.