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The side effects of toremifene are similar to those of tamoxifen. [5] The most common side effect is hot flashes. [5] Other side effects include sweating, nausea, vomiting, dizziness, vaginal discharge, and vaginal bleeding. [5] [7] In women with bone metastases, hypercalcemia may occur. [5] Toremifene has a small risk of thromboembolic events. [5]
Tamoxifen is more promiscuous than raloxifene in target sites because of the relationship between ER's amino acid in Asp-351 and the antiestrogenic side chain of the SERM. The side chain for tamoxifen cannot neutralize Asp-351, so the site allosterically influences AF-1 at the proximal end of the ER. This issue is mended with the second ...
In general, the safety and effectiveness of alternative medicines have not been scientifically proven [1] and remain largely unknown. [2] Beyond adverse effects from the herb itself, "adulteration, inappropriate formulation , or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life ...
Tamoxifen treatment of postmenopausal women is associated with beneficial effects on serum lipid profiles. However, long-term data from clinical trials have failed to demonstrate a cardioprotective effect. [54] For some women, tamoxifen can cause a rapid increase in triglyceride concentration in the blood.
Adverse effects can also occur in the urinary, central or peripheral nervous, or musculoskeletal systems. [35] A review of clinical trials studying bioidentical progesterone use found that it was ineffective in managing vasomotor symptoms of menopause, but had mild and self-limiting side effects. [36]
Ormeloxifene may be used as a weekly oral contraceptive. [6] The weekly schedule is an advantage for women who prefer an oral contraceptive, but find it difficult or impractical to adhere to a daily schedule required by other oral contraceptives.
10 Natural Minoxidil Alternatives. Complementary and alternative medicine, often called natural medicine or natural treatments, are those outside the realm of your doctor’s prescribed medications.
A nonsteroidal estrogen is an estrogen with a nonsteroidal chemical structure. [1] The most well-known example is the stilbestrol estrogen diethylstilbestrol (DES). [1] [2] Although nonsteroidal estrogens formerly had an important place in medicine, they have gradually fallen out of favor following the discovery of toxicities associated with high-dose DES starting in the early 1970s, and are ...