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Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
Slip-ons are typically low, lace-less shoes. [1] The style which is most commonly seen, known as a loafer , slippers , or penny loafers in American culture, has a moccasin construction. One of the first designs was introduced in London by Wildsmith Shoes , called the Wildsmith Loafer. [ 2 ]
Us Weekly has affiliate partnerships so we may receive compensation for some links to products and services. Slippers are the ultimate slip-on shoes, but they tend to be reserved for at-home use.
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SIRT1 protein promotes homologous recombination in human cells and is involved in recombinational repair of DNA breaks. [ 29 ] SIRT6 is a chromatin -associated protein and in mammalian cells is required for base excision repair of DNA damage . [ 30 ]
UniProt Archive (UniParc) is a comprehensive and non-redundant database, which contains all the protein sequences from the main, publicly available protein sequence databases. [17] Proteins may exist in several different source databases, and in multiple copies in the same database.
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