Search results
Results from the WOW.Com Content Network
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [ 5 ] [ 6 ] CTCF is involved in many cellular processes, including transcriptional regulation , insulator activity, V(D)J recombination [ 7 ] and regulation of chromatin architecture.
The nuclear–cytoplasmic ratio (also variously known as the nucleus:cytoplasm ratio, nucleus–cytoplasm ratio, N:C ratio, or N/C) is a measurement used in cell biology. It is a ratio of the size (i.e., volume) of the nucleus of a cell to the size of the cytoplasm of that cell. [1]
The average size of a topologically associating domain (TAD) is 1000 kb in humans, 880 kb in mouse cells, and 140 kb in fruit flies. [ 2 ] [ 3 ] Boundaries at both side of these domains are conserved between different mammalian cell types and even across species [ 2 ] and are highly enriched with CCCTC-binding factor (CTCF) and cohesin . [ 1 ]
Unit cell definition using parallelepiped with lengths a, b, c and angles between the sides given by α, β, γ [1]. A lattice constant or lattice parameter is one of the physical dimensions and angles that determine the geometry of the unit cells in a crystal lattice, and is proportional to the distance between atoms in the crystal.
Two of these cell cycle regulation genes that are known to interact with CTCF are hTERT and C-MYC. In these cases, a loss of function mutation to the CTCF insulator gene changes the expression patterns and may affect the interplay between cell growth, differentiation and apoptosis and lead to tumourigenesis or other problems. [2]
A cellular automaton consists of a regular grid of cells, each in one of a finite number of states, such as on and off (in contrast to a coupled map lattice). The grid can be in any finite number of dimensions. For each cell, a set of cells called its neighborhood is defined relative to the specified cell.
Chargaff's rules (given by Erwin Chargaff) state that in the DNA of any species and any organism, the amount of guanine should be equal to the amount of cytosine and the amount of adenine should be equal to the amount of thymine. Further, a 1:1 stoichiometric ratio of purine and pyrimidine bases (i.e., A+G=T+C) should exist. This pattern is ...
There are two major ways of normalizing raw Hi-C contact heat maps. The first way is to assume equal visibility, meaning there is an equal chance for each chromosomal position to have an interaction. Therefore, the true signal of a Hi-C contact map should be a balanced matrix (Balanced matrix has constant row sums and column sums).