Search results
Results from the WOW.Com Content Network
Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. [1] Affected individuals have up to twice the usual amount of muscle mass in their bodies, but increases in muscle strength are not usually congruent. [ 2 ]
A monoclonal antibody specific to myostatin increases muscle mass in mice [40] and monkeys. [25] A two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and binds to myostatin, leads to a significantly increased muscle mass (up to 60%). [41]
Myostatin inhibitors were generally able to increase lean body mass and reduce body fat in people with sarcopenia, but the extent to which this translated into functional improvements varied. [11] Bimagrumab showed effectiveness in increasing lean mass and reducing fat mass in obese individuals in a clinical trial. [11]
Sarcopenic obesity is a combination of two disease states, sarcopenia and obesity.Sarcopenia is the muscle mass/strength/physical function loss associated with increased age, [1] and obesity is based off a weight to height ratio or body mass index (BMI) that is characterized by high body fat or being overweight.
Myostatin, a TGF-beta superfamily member, is a negative regulator of muscle growth. [1] Myostatin binds to ACVR2B and to a lesser extent ACVR2A. In mice that were ACVR2A −/− mutants there was an increase in all four muscle groups studied (pectoralis, triceps, quadriceps, and gastrocnemious/plantaris muscles). [1] Two of these muscle groups ...
The definition and use of the term myokine first occurred in 2003. [5] In 2008, the first myokine, myostatin, was identified. [4] [6] The gp130 receptor cytokine IL-6 (Interleukin 6) was the first myokine found to be secreted into the blood stream in response to muscle contractions.
The exact cause is unclear. A combination of consistent findings on physical examination, the presence of anti HMG-CoA reductase antibodies in a person with myopathy, evidence of muscle breakdown, and muscle biopsy diagnose SAAM. [3] Treatment involves stopping the associated statin medication and taking medication to suppress the immune system.
Pages in category "People with Myostatin-related muscle hypertrophy" This category contains only the following page. This list may not reflect recent changes. H.