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Keap1 has four discrete protein domains. The N-terminal Broad complex, Tramtrack and Bric-à-Brac (BTB) domain contains the Cys151 residue, which is one of the important cysteines in stress sensing. The intervening region (IVR) domain contains two critical cysteine residues, Cys273 and Cys288, which are a second group of cysteines important for ...
Schematic diagram of NF-κB protein structure. [1] There are two structural classes of NF-κB proteins: class I (top) and class II (bottom). Both classes of proteins contain a N-terminal DNA-binding domain (DBD), which also serves as a dimerization interface to other NF-κB transcription factors and, in addition, binds to the inhibitory IκBα ...
The Center comprises a wide range of expertise and skills within research areas of disease systems biology, proteomics, high throughput protein production and characterisation, chemical biology, disease biology, and protein therapeutics. The Center also contributes to the progress of translational research within medicine and provide ...
Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson's disease. Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested.
The Annual Review of Animal Biosciences is a peer-reviewed scientific journal published by Annual Reviews. It releases an annual volume of review articles relevant to the fields of zoology, veterinary medicine, animal husbandry, and conservation biology. It has been in publication since 2013. The co-editors are Harris A. Lewin and R. Michael ...
PIR was established in 1984 by the National Biomedical Research Foundation as a resource to assist researchers and customers in the identification and interpretation of protein sequence information. Prior to that, the foundation compiled the first comprehensive collection of macromolecular sequences in the Atlas of Protein Sequence and ...
This gene encodes a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N.
A classification model (classifier or diagnosis [7]) is a mapping of instances between certain classes/groups.Because the classifier or diagnosis result can be an arbitrary real value (continuous output), the classifier boundary between classes must be determined by a threshold value (for instance, to determine whether a person has hypertension based on a blood pressure measure).