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The bullae are formed by an immune reaction, initiated by the formation of IgG [citation needed] autoantibodies targeting dystonin, also called bullous pemphigoid antigen 1, [6] and/or type XVII collagen, also called bullous pemphigoid antigen 2, [7] which is a component of hemidesmosomes. A different form of dystonin is associated with ...
Pemphigus foliaceus skin eruption on the abdomen of a dog. Pemphigus foliaceus has been recognized in pet dogs, cats, and horses, and is the most common autoimmune skin disease diagnosed in veterinary medicine. PF in animals produces clusters of small vesicles that quickly evolve into pustules. Pustules may rupture, forming erosions or become ...
However, in dogs affected by an autoimmune disease, the immune system loses the ability to make this distinction, causing the immune system to attack the body. [5] Autoimmune diseases in the base layer of the epidermis are characterized by damage to the connective tissue and vesicle formation located below the epidermis layer and the dermis ...
Bullous pemphigoid is most commonly seen in Dobermanns and Collies and appears as a scald-like lesion of the groin. [83] Sebaceous adenitis is an uncommon autoimmune skin disease. Most commonly found in Akitas and Standard Poodles. [84]
Bites and stings as well as other conditions (e.g. drug reactions, urticarial reactions, and early bullous pemphigoid) can cause microscopic changes such as a wedge-shaped superficial dermal perivascular infiltrate consisting of abundant lymphocytes and scattered eosinophils, as shown in the adjacent figure: [12]
Antibody isotype(s) and location of antibody deposition in immunofluorescence studies using salt-split skin for autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system Condition Antibody isotype(s) deposited Localization of antibody with use of salt-split skin Antiepilegrin cicatricial pemphigoid ...
Pemphigoid is a group of rare autoimmune blistering diseases of the skin and mucous membranes.As its name indicates, pemphigoid is similar in general appearance to pemphigus, [1] however unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells.
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