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Bis(2-ethylhexyl) phthalate (di-2-ethylhexyl phthalate, diethylhexyl phthalate, diisooctyl phthalate, DEHP; incorrectly — dioctyl phthalate, DIOP) is an organic compound with the formula C 6 H 4 (CO 2 C 8 H 17) 2. DEHP is the most common member of the class of phthalates, which are used as plasticizers.
This includes Bis(2-ethylhexyl) phthalate (DEHP or DOP), which has long been the most widely used phthalate, with commercial production dating back to the 1930s. [ 16 ] [ 17 ] In the EU, the use of DEHP is restricted under REACH and it can only be used in specific cases if an authorisation has been granted; similar restrictions exist in many ...
On 16 April 2021, the FDA revoked the emergency use authorization (EUA) for the investigational monoclonal antibody therapy bamlanivimab, when administered alone, to be used for the treatment of mild-to-moderate COVID-19 in adults and certain pediatric patients.
In combination with palbociclib and fulvestrant for the treatment of adults with endocrine-resistant, PIK3CA-mutated, hormone receptor (HR)-positive, human epidermal growth-factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer, as detected by an FDA-approved test, following recurrence on or after completing adjuvant ...
The enzyme bis(2-ethylhexyl)phthalate esterase (EC 3.1.1.60) catalyzes the reaction bis(2-ethylhexyl)phthalate + H 2 O 2-ethylhexyl phthalate + 2-ethylhexan-1-ol Action of the enzyme. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds.
An Emergency Use Authorization (EUA) in the United States is an authorization granted to the Food and Drug Administration (FDA) under sections of the Federal Food, Drug, and Cosmetic Act as added to and amended by various Acts of Congress, including by the Pandemic and All-Hazards Preparedness Reauthorization Act of 2013 (PAHPRA), as codified by 21 U.S.C. § 360bbb-3, to allow the use of a ...
TBPH is the brominated analogue of bis(2-ethylhexyl) phthalate (DEHP). Much like TBPH, DEHP has been widely used as a plasticizer , however unlike TBPH, it is currently a restricted substance due to its endocrine disrupting properties and reproductive toxicity . [ 6 ]
Bis(2-ethylhexyl) terephthalate commonly abbreviated DEHT (Dioctyl terephthalate or DOTP), is an organic compound with the formula C 6 H 4 (CO 2 C 8 H 17) 2. It is a non- phthalate plasticizer , being the diester of terephthalic acid and the branched-chain 2-ethylhexanol , which is often generically referred to as octyl.