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Senescent cells have a low pH due to their high lysosomal content and leaking lysosomal membranes. This low pH forms the basis of senescence-associated beta-galactosidase (SA-β-gal) staining of senescent cells. To help neutralize their low pH, senescent cells produce high levels of GLS1; inhibiting the activity of this enzyme exposes senescent ...
Cellular senescence is a phenomenon characterized by the cessation of cell division. [ 1 ][ 2 ][ 3 ] In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent. [ 4 ][ 5 ][ 6 ] This ...
ABT-737 is a small molecule drug that inhibits Bcl-2 and Bcl-xL, two members of the Bcl-2 family of evolutionarily-conserved proteins that share B cl-2 H omology (BH) domains. First developed as a potential cancer chemotherapy, [1] it was subsequently identified as a senolytic (a drug that selectively induces cell death in senescent cells).
The vasodilatory actions of nitric oxide play a key role in renal control of extracellular fluid homeostasis and is essential for the regulation of blood flow and blood pressure. [51] NO also plays a role in erection of the penis and clitoris. [52] Nitric oxide also acts on cardiac muscle to decrease contractility and heart rate. NO contributes ...
The pulmonary circulation is a division of the circulatory system in all vertebrates. The circuit begins with deoxygenated blood returned from the body to the right atrium of the heart where it is pumped out from the right ventricle to the lungs. In the lungs the blood is oxygenated and returned to the left atrium to complete the circuit.
Pulmonary surfactant. Alveoli are the spherical outcroppings of the respiratory bronchioles. Pulmonary surfactant is a surface-active complex of phospholipids and proteins formed by type II alveolar cells. [1] The proteins and lipids that make up the surfactant have both hydrophilic and hydrophobic regions.
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). [3] Specifically it is used to treat cases that are Philadelphia chromosome -positive (Ph+). [3] It is taken by mouth.
Hypoxemia refers to insufficient oxygen in the blood. Thus any cause that influences the rate or volume of air entering the lungs (ventilation) or any cause that influences the transfer of air from the lungs to the blood may cause hypoxemia. As well as these respiratory causes, cardiovascular causes such as shunts may also result in hypoxemia.
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