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  2. Cross-linking immunoprecipitation - Wikipedia

    en.wikipedia.org/wiki/Cross-linking_immuno...

    Cross-linking and immunoprecipitation (CLIP, or CLIP-seq) is a method used in molecular biology that combines UV crosslinking with immunoprecipitation in order to identify RNA binding sites of proteins on a transcriptome-wide scale, thereby increasing our understanding of post-transcriptional regulatory networks.

  3. Fc receptor - Wikipedia

    en.wikipedia.org/wiki/Fc_receptor

    In immunology, an Fc receptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells, natural killer cells, macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells – that contribute to the protective functions of the immune system.

  4. Chromatin immunoprecipitation - Wikipedia

    en.wikipedia.org/wiki/Chromatin_immunoprecipitation

    The agent for reversible cross-linking could be formaldehyde [3] or UV light. [4] Then the cross-linked chromatin is usually sheared by sonication, providing fragments of 300 - 1000 base pairs (bp) in length. Mild formaldehyde crosslinking followed by nuclease digestion has been used to shear the chromatin. [5]

  5. Cross-link - Wikipedia

    en.wikipedia.org/wiki/Cross-link

    In vulcanization, sulfur is the cross-linking agent. Its introduction changes rubber to a more rigid, durable material associated with car and bike tires. This process is often called sulfur curing. In most cases, cross-linking is irreversible, and the resulting thermosetting material will degrade or burn if heated, without melting. Chemical ...

  6. FCER1 - Wikipedia

    en.wikipedia.org/wiki/FCER1

    FcεRI cross-linking by IgE and anti-IgE antibodies led to Th2 (IL-4, -5, and -13) cytokines and CCL11/eotaxin-1 chemokine release; and ([Ca2+]i) mobilization, suggesting a likely IgE-FcεRI-ASM (airway smooth muscle cell)-mediated link to airway inflammation and airway hyperresponsiveness.

  7. T independent antigen (TI) - Wikipedia

    en.wikipedia.org/wiki/T_independent_antigen_(TI)

    T independent antigens elicit antibody production by B lymphocytes without T lymphocyte involvement. There are two distinct subgroups of TI antigens, different in mechanism of activating B lymphocytes: TI-1 antigen, which has an activity that can directly activate B cells and TI-2 antigen, which has highly repetitive structure and causes simultaneous cross-linking of specific B cell receptors ...

  8. CD16 - Wikipedia

    en.wikipedia.org/wiki/CD16

    In a normal, healthy individual, cross-linking of CD16 (FcγRIII) by immune complexes induces antibody-dependent cellular cytotoxicity (ADCC) in NK cells. However, this pathway can also be targeted in cancerous or diseased cells by immunotherapy.

  9. B-cell receptor - Wikipedia

    en.wikipedia.org/wiki/B-cell_receptor

    The first checkpoint in the development of a B cell is the production of a functional pre-BCR, which is composed of two surrogate light chains and two immunoglobulin heavy chains, which are normally linked to Ig-α (or CD79A) and Ig-β (or CD79B) signaling molecules.