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Myelin basic protein (MBP) is a protein believed [weasel words] to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction . [ 5 ]
Mature oligodendrocyte: After myelinogenesis, mature oligodendrocytes surround axons in organized, multilamellar myelin sheaths that contain myelin basic protein (MBP) and myelin proteolipid protein (PLP). Myelinogenesis thus encompasses the process of transition between phases 3 and 4. [6]
They differentiate into the less mobile premyelinating oligodendrocytes that further differentiate into oligodendrocytes, [35] a process characterized by the emergence of the expression of myelin basic protein (MBP), proteolipid protein (PLP), or myelin-associated glycoprotein (MAG). [28]
Structurally the major basic protein (MBP) is similar to lectins (sugar-binding proteins), and has a fold similar to that seen in C-type lectins. However, unlike other C-type lectins (those that bind various carbohydrates in the presence of calcium), MBP does not bind either calcium or any of the other carbohydrates that this family recognize.
In terms of total mass, myelin comprises approximately 40% water; the dry mass comprises between 60% and 75% lipid and between 15% and 25% protein. Protein content includes myelin basic protein (MBP), [21] which is abundant in the CNS where it plays a critical, non-redundant role in formation of compact myelin; myelin oligodendrocyte ...
Milk basic protein, a milk protein fraction; Myc-binding protein-1, a protein encoded by the alpha-enolase glycolytic enzyme; Myelin basic protein, a protein believed to be important in the process of myelination of nerves in the central nervous system; Mannan-binding lectin (also mannose- or mannan-binding protein), an important factor in ...
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Using a novel protocol, myelin basic protein (MBP), a marker for oligodendrocyte differentiation and myelination in the CNS, was detectable as early as day 63 (9 weeks) and myelinated axons were observed by day 105 (15 weeks), effectively halving the duration of the protocol. [17] [18]
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