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Isoniazid has a boxed warning for severe and sometimes fatal hepatitis, which is age-dependent at a rate of 0.3% in people 21 to 35 years old and over 2% in those over age 50. [ 25 ] [ 37 ] Symptoms suggestive of liver toxicity include nausea, vomiting, abdominal pain, dark urine, right upper quadrant pain, and loss of appetite. [ 25 ]
It combines isoniazid, pyridoxine, sulfamethoxazole, and trimethoprim. [1] Specifically it is used to prevent tuberculosis, toxoplasmosis, pneumonia, malaria, and isosporiasis. [2] It is taken by mouth. [1] Side effects may include trouble concentrating, numbness, vomiting, and rash. [2] Serious side effects may include liver problems. [2]
The main result was a relative risk (RR) of 0.40 (95% confidence interval (CI) 0.31 to 0.52) for development of active tuberculosis over two years or longer for patients treated with INH, with no significant difference between treatment courses of six or 12 months (RR 0.44, 95% CI 0.27 to 0.73 for six months, and 0.38, 95% CI 0.28 to 0.50 for ...
On 28 December 2012, the U.S. Food and Drug Administration (FDA) approved bedaquiline (marketed as Sirturo by Johnson & Johnson) to treat multidrug-resistant tuberculosis, the first new treatment in 40 years. Sirturo is to be used in a combination therapy for patients who have failed standard treatment and have no other options.
The ladies are all pushing 80 -- Mimi is 75, Annette is 72 and Linda is 71 -- but they look decades younger. Not a single one of those women looked over 40, let 'Steve Harvey' features women in ...
Methoxyflurane, sold under the brand name Penthrox among others, is an inhaled medication primarily used to reduce pain following trauma. [5] [6] It may also be used for short episodes of pain as a result of medical procedures. [4]
It is generally well tolerated with few significant side effects. [1] Side effects may include irregular menstrual periods, no periods, headaches, and breast pain. [3] [4] Use is not recommended in people with significant liver disease. [3] The levonorgestrel implant is a type of long-acting reversible birth control. [5]
It is a fixed dose combination of ethambutol, isoniazid, pyrazinamide, and rifampicin. [1] It is used either alone or with other antituberculosis medication. [1] It is taken by mouth. [1] Side effects are those of the underlying medications. [1] Pyridoxine may be used to decrease the risk of numbness. [2]